Human brain clearance imaging - Literature

Relevant Literature

Rasmussen MK, Mestre H, Nedergaard M. Fluid transport in the brain. Physiol Rev. 2022 Apr 1;102(2):1025-1151. doi: https://doi.org/10.1152/physrev.00031.2020. Epub 2021 May 5. PMID: 33949874; PMCID: PMC8897154.
Mestre H, Mori Y, Nedergaard M. The Brain's Glymphatic System: Current Controversies. Trends Neurosci. 2020 Jul;43(7):458-466. doi: https://doi.org/10.1016/j.tins.2020.04.003. Epub 2020 May 15. PMID: 32423764; PMCID: PMC7331945.
Brinker, T., Stopa, E., Morrison, J., & Klinge, P. (2014). A new look at cerebrospinal fluid circulation. Fluids and barriers of the CNS, 11, 10. https://doi.org/10.1186/2045-8118-11-10
Jessen, N. A., Munk, A. S., Lundgaard, I., & Nedergaard, M. (2015). The Glymphatic System: A Beginner's Guide. Neurochemical research, 40(12), 2583–2599. https://doi.org/10.1007/s11064-015-1581-6
Plog, B. A., & Nedergaard, M. (2018). The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future. Annual review of pathology, 13, 379–394. https://doi.org/10.1146/annurev-pathol-051217-111018

Benveniste, H., Lee, H., & Volkow, N. D. (2017). The Glymphatic Pathway: Waste Removal from the CNS via Cerebrospinal Fluid Transport. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 23(5), 454–465. https://doi.org/10.1177/1073858417691030
Zhao L, Tannenbaum A, Bakker ENTP, and Benveniste H (2022). Physiology of Glymphatic Solute Transport and Waste Clearance from the Brain. Physiology202237:6,349-362. https://doi.org/10.1152/physiol.00015.2022
Davies, J., Siebenhandl-Wolff, P., Tranquart, F. et al. Gadolinium: pharmacokinetics and toxicity in humans and laboratory animals following contrast agent administration. Arch Toxicol 96, 403–429 (2022). https://doi.org/10.1007/s00204-021-03189-8
Wardlaw JM, Benveniste H, Nedergaard M, et al. Perivascular spaces in the brain: anatomy, physiology and pathology. Nat Rev Neurol. 2020;16(3):137-153. doi: https://doi.org/10.1038/s41582-020-0312-z
Benveniste, H., Liu, X., Koundal, S., Sanggaard, S., Lee, H., & Wardlaw, J. (2019). The Glymphatic System and Waste Clearance with Brain Aging: A Review. Gerontology, 65(2), 106–119. https://doi.org/10.1159/000490349

Ringstad G, Valnes LM, Dale AM, Pripp AH, Vatnehol SS, Emblem KE, Mardal KA, Eide PK. Brain-wide glymphatic enhancement and clearance in humans assessed with MRI. JCI Insight. 2018 Jul 12;3(13):e121537. doi: https://doi.org/10.1172/jci.insight.121537. PMID: 29997300.
Per Kristian Eide, Vegard Vinje, Are Hugo Pripp, Kent-Andre Mardal, Geir Ringstad, Sleep deprivation impairs molecular clearance from the human brain, Brain, Volume 144, Issue 3, March 2021, Pages 863–874, https://doi.org/10.1093/brain/awaa443
Hornkjøl M, Valnes LM, Ringstad G, Rognes ME, Eide PK, Mardal KA, Vinje V. CSF circulation and dispersion yield rapid clearance from intracranial compartments. Front Bioeng Biotechnol. 2022 Sep 12;10:932469. doi: 10.3389/fbioe.2022.932469.
Zapf B, Haubner J, Kuchta M, Ringstad G, Eide PK, Mardal KA. Investigating molecular transport in the human brain from MRI with physics-informed neural networks. Sci Rep. 2022 Sep 14;12(1):15475. doi: 10.1038/s41598-022-19157-w. PMID: 36104360; PMCID: PMC9474534.

Fultz NE, Bonmassar G, Setsompop K, Stickgold RA, Rosen BR, Polimeni JR, Lewis LD. Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep. Science. 2019 Nov 1;366(6465):628-631. doi: https://doi.org/10.1126/science.aax5440. PMID: 31672896.
Eide PK, Pripp AH, Berge B, Hrubos-Strøm H, Ringstad G, Valnes LM. Altered glymphatic enhancement of cerebrospinal fluid tracer in individuals with chronic poor sleep quality. J Cereb Blood Flow Metab. 2022 Sep;42(9):1676-1692. doi: 10.1177/0271678X221090747.
Ringstad G, Eide PK. Molecular trans-dural efflux to skull bone marrow in humans with CSF disorders. Brain. 2022 May 24;145(4):1464-1472. doi: 10.1093/brain/awab388.
Deike-Hofmann K, Reuter J, Haase R, Paech D, Gnirs R, Bickelhaupt S, Forsting M, Heußel CP, Schlemmer HP, Radbruch A. Glymphatic Pathway of Gadolinium-Based Contrast Agents Through the Brain: Overlooked and Misinterpreted. Invest Radiol. 2019 Apr;54(4):229-237. doi: https://doi.org/10.1097/RLI.0000000000000533. PMID: 30480554.

Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., Nagelhus, E. A., & Nedergaard, M. (2012). A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Science translational medicine, 4(147), 147ra111. https://doi.org/10.1126/scitranslmed.3003748
Iliff, J. J., Wang, M., Zeppenfeld, D. M., Venkataraman, A., Plog, B. A., Liao, Y., Deane, R., & Nedergaard, M. (2013). Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(46), 18190–18199. https://doi.org/10.1523/JNEUROSCI.1592-13.2013

Kress, B. T., Iliff, J. J., Xia, M., Wang, M., Wei, H. S., Zeppenfeld, D., Xie, L., Kang, H., Xu, Q., Liew, J. A., Plog, B. A., Ding, F., Deane, R., & Nedergaard, M. (2014). Impairment of paravascular clearance pathways in the aging brain. Annals of neurology, 76(6), 845–861. https://doi.org/10.1002/ana.24271
Hablitz, L. M., Plá, V., Giannetto, M., Vinitsky, H. S., Stæger, F. F., Metcalfe, T., Nguyen, R., Benrais, A., & Nedergaard, M. (2020). Circadian control of brain glymphatic and lymphatic fluid flow. Nature communications, 11(1), 4411. https://doi.org/10.1038/s41467-020-18115-2